Saturday, 4 March 2017

SULFA DRUGS & THEIR COMBINATIONS AGAINST STATIONARY PHASE LYME DISEASE IN VITRO

Activity of Sulfa Drugs and Their Combinations against Stationary Phase B. burgdorferi in vitro

Jie FengShuo ZHANGWanliang ShiYING ZHANG

COMPOUND TO TREAT DORMANT PHASE OF LYME DISEASE





Published on Nov 22, 2016
The entire interview conducted for Lyme & Reason 2.0

I had not seen this full interview before which is especially interesting in that his team are researching a compound to work on the dormant phase of Borrelia. It is already FDA approved for use in another field. They are currently doing mouse studies and hope to lead to further human studies.
This work is due to be published in six months he says.
Thanks to Fox 5 NY for their in depth coverage of Lyme and Reason I posted earlier with links 
https://lookingatlyme.blogspot.co.uk/2016/07/fox-5-lyme-and-reason.html  

Fox5NY has been nominated for 3 Emmy awards https://www.lymedisease.org/lyme-reason-emmy-nom/

Fox5NY are already the winners in the hearts of many thousands of Lyme patients the World over for bringing our plight into the limelight and public consciousness.

 earlier videos of prof Kim Lewis

Friday, 17 February 2017

CANADA FIGHTS BACK - LYME DISEASE Please help.

Ticking Lyme Bomb in Canada. YOU are at RISK. Sign now!




Lyme disease is one of the fastest spreading infectious diseases in the world.

Please sign this petition by March 1, 2017 asking the Canadian Government to reject the current draft Action Plan (Framework) for Lyme disease and FIX IT.

 The Framework must recognize the seriousness of this disease for all of us.

 Time is ticking. Canada has NO Plan.

https://www.change.org/p/minister-philpott-ticking-lyme-bomb-in-canada-fix-canada-s-lyme-action-plan-now

Sunday, 5 February 2017

A CALL FOR CULTURE TESTS FOR LYME DISEASE AND ALL BORRELIOSIS

Lyme disease, or Lyme borreliosis, in North America is a group of systemic infections which may be caused by Borrelia burgdorferi sensu lato (including B. mayonii) [2], B. miyamotoi [3-5], and other unnamed tick-borne borrelia strains [3, 6]. Currently the diagnosis of emerging or reemerging infectious diseases largely depends on finding evidence of the causative agents, including borrelia, in the host by nucleic acid-based tests [7]. The accuracy of any diagnostic tests must be measured against this standard of microbiological diagnosis. Using a serologic test kit developed for the detection of antibodies against the epitopes of B. burgdorferi sensu stricto strain B31 will fail to diagnose most Lyme borreliosis patients in the first two weeks of acute infection and probably all clinical Lyme borreliosis cases caused by a strain of borrelia other than B. burgdorferi sensu stricto B31 at any stages of the disease. The inherent inaccuracy of serologic tests for Lyme disease can be compared with that of the Widal test for the diagnosis of typhoid or paratyphoid fever (Salmonella infections). A comment extracted from a Centers for Disease Control and Prevention (CDC) document is copied as follows [8]. “The Widal test is unreliable but is widely used in developing countries because of its low cost. It is a serologic assay for IgM and IgG to the O and H antigens of Salmonella Typhi, but is not specific and false positives may occur. Acute- and convalescent-phase titers are more sensitive than a single serum sample. Newer serologic assays for Salmonella Typhi infection are occasionally used in outbreak situations, and are somewhat more sensitive and specific than the Widal test, but are not an adequate substitute for blood, stool, or bone marrow culture.” 

The above is an extract from Sin Hang Lee, F.R.C.P.(C) Director, Milford Molecular Diagnostics Laboratory comments on a recent published article - “The Accuracy of Diagnostic Tests for Lyme Disease in Humans, A Systematic Review and Meta-Analysis of North American Research” by Lisa A. Waddell and colleagues

My earlier post https://lookingatlyme.blogspot.co.uk/2017/01/over-reliance-on-lyme-disease-tests.html also refers to this, which was discussed by Mary Beth Pfeiffer investigative journalist in a Huffington post article http://www.huffingtonpost.com/entry/flunk-the-lyme-test-just-wait-and-get-sicker_us_5873ef2fe4b08052400ee537?


Dr Lee's detailed comments can be read in full at  https://canlyme.com/2017/01/31/canadian-tax-payer-funded-lyme-research-not-good-value-for-dollar/

Dr Lee finishes his comments by saying :-

To overcome the low sensitivity of LD diagnostic tests in patients with early LD at the spirochetemic stage, we must first acknowledge a need to develop direct detection tests for Borrelia burgdorferi and related borrelia species known to cause Lyme borreliosis in North America. To survey the existent useful direct detection tests which may not have been published due to global editorial censorship by the mainstream medical journals, it is recommended that blind-coded simulated blood samples spiked with various species of known borreliae or blank be distributed by government regulatory agencies to all clinical laboratories performing Lyme disease testing for a bacteriology proficiency survey, as routinely conducted by the College of American Pathologists for Neisseria gonorrhoeae. The laboratories which return the correct answers would be invited to further develop a generally accepted diagnostic protocol to be used by hospital laboratories located in Lyme disease-endemic areas. To be of use for timely patient care, the results must be generated within 5 working days, preferably in 48 hours. I believe this technology is already available. The first step to the Lyme disease solution is to cut out the tribalism among the scientists whose careers were built on Lyme disease research. 

Tuesday, 10 January 2017

OVER RELIANCE ON LYME DISEASE TESTS CAUSES HEALTH BURDEN

Flunk the Lyme test? Just wait and get sicker 


"Sin Lee, a pathologist and scientist, believes the deck is stacked in the quest to air new ideas on Lyme disease.
Too many science journals telling him to take his research elsewhere. Too many deftly worded rejections. Too little inclination to engage in a fair fight over the facts and fiction of Lyme disease.
Dr. Lee’s experience is shared by many researchers I have interviewed, in the U.S. and Europe, in five years of writing about a disease on which scientific debate is limited and tightly controlled. Some 380,000 Americans were infected with the tick-borne spirochete in 2015, leaving 20,000, by conservative estimates, with unresolved joint pain, cognitive lapses, fatigue and other problems. Another 232,000 are estimated to be infected annually in Western Europe. Many suffer because of a poor test and delayed diagnoses, issues that have been largely dismissed in mainstream journals."
Go to this link to read this excellent in depth article in full -
Thanks to the Huffington post for publishing this article written by Mary Beth Pfeiffer investigative journalist who is writing a book, 'The First Epidemic,' on the global spread of ticks and the diseases they carry.

Lyme disease reporting by Mary Beth Pfeiffer
September 7, 2016: CDC Says Fewer Suffer After Lyme Disease. Doesn’t Say, If Treated Early.

July 16, 2016: Go-To Lyme Drugs Don't Always Kill The Bug

May 30: 2016: ‘Quiet Plague’ Claims Another Celebrity
April 5, 2016: Lyme Time Is upon Us Again
Major installments in Poughkeepsie Journal series No Small Thing, 2012-2015
August 19, 2012: Lyme disease: Antibiotics Fuel Debate

October 21, 2012: Flunking the Lyme disease test Dicey path to Lyme diagnosis Centers for Disease Control says tests 'almost always' correct, but the pitfalls are many  

CDC researcher answers questions on disease, tests 

November 18, 2012: Counting the Lyme disease toll; Cases soar in the Northeast; CDC admits undercounting but declines 'epidemic' labelhttp://www.poughkeepsiejournal.com/story/news/health/lyme-disease/2014/03/21/lyme-counting-imprecise/6698009/

December 23, 2012: Babesiosis and the blood supply: Tiny tick, big threat http://www.poughkeepsiejournal.com/story/news/health/2014/03/24/lyme-babesiosis-threat/6699087/

December 24, 2012: The next tick scourge:Dutchess at center of rising tick threat http://www.poughkeepsiejournal.com/story/news/health/lyme-disease/2014/03/21/lyme-dutchess-tick-threat/6699395/
2013
May 19, 2013: Chronic Lyme disease: Is it real? 
Sidebar: Lyme emails request took five years; officials blame scope and fee waiver

Sept. 15, 2013: Doctors Bucking Lyme Protocols

Sept. 22, 2013: Battle shifts over Lyme disease 

Oct. 6, 2013: Lyme deaths: 9 in N.Y., 5 in valley

Dec. 23, 2013: Sudden Death: Beacon father, husband, 38, is 1 of 3 killed by Lyme disease heart condition; warning issued
2014
Aug. 4, 2014: Dogs, horses show high rates of Lyme disease
http://www.poughkeepsiejournal.com/story/news/investigations/2014/08/02/bitten/13313003/

Aug. 5, 2014: Lyme Disease Treatment Cost Soars
2015
May 31, 2015 Review of Lyme disease treatment leaves out patients